Van de makers van Spring Breakers, krijgen we Matthew McConaughey als drugsnemende dichter in The Beach Bum. McConaughey (Interstellar, Gold, Wolf of Wall Street) wordt verder ondersteund door Zac Efron (The Greatest Showman, Baywatch), Snoop Dogg (Training Day, Starsky & Hutch), Isla Fisher (Confessions of a Shopaholic, Now You See Me, Tag, Nocturnal Animals), Martin Lawrence (Bad Boys for Life) & Jonah Hill (Maniac, Superbad, 21 Jump Street).